Polio vaccines are significantly sensitive to temperature and environment. During polio vaccination campaigns in far off villages of Pakistan, it is one of the biggest challenges to store and transport the vaccine without affecting its quality. Various refrigeration techniques are used to keep the vaccine below ambient temperature. The energy consumption of conventional refrigeration systems is too high and the refrigerants having CFCs are hazardous to environment, contributing to global warming by depleting ozone layer. These are also slightly difficult to be developed into a lightweight and portable solar devices used outside. Solar Powered Thermoelectric Refrigerator (SPTR) is a distinct type of refrigeration system which runs on solar energy rather than that of conventional source of electrical energy, based upon the peltier effect to create hot and cold sides. The current research work was carried out at the Mechanical Engineering Department, U.E.T. Lahore (KSK Campus). The experimental results indicated the unit is capable to maintain a temperature of 6 0C at an ambient temperature below that of 50 0C. The maximum coefficient of performance was recorded as 0.78. Special configuration of heat sink was used to get maximum heat dissipation with minimum cost. An optimal value of solar irradiance let the cooling rate and coefficient of performance to attain maximum value. The designed SPTR would be of a great potential for cold storage in the areas where electricity supply is absent. It has the advantages of being small, lightweight, low running cost, noiseless, portable, reliable, and also low initial cost in mass production.