South China Sea’s geopolitics is affecting the region as the two major global powers, China and the US are the parties in this conflict. Both have varying geopolitical interests which needs to be analysed to understand the regional geopolitics. To determine their ties, this paper focus on understanding the differences between the two states, the growing power and affirmation of China, and its priorities and policies in search and protection of its interests. There is a disparity in the region where China is trying to strengthen its position in the area, while America wishes to uphold the existing status quo. The paper argues that, in such situation, it is hard to see prospects for Chinese-US collaboration in the South China Sea.