Qazi Mohammad Isa was a prominent political leader from Baluchistan who played pivotal role in the Pakistan Movement. As right hand of Quaid-i-Azam Mohammad Ali Jinnah, the founder of Pakistan, he organized the Muslim League in Baluchistan as its President during 1939-1947 and did help popularize the Pakistan Movement in the Baluchistan province. As member of Central Council of the All India Muslim League, he also toured different provinces of British India especially the Sindh, Punjab and NWFP (now KPK) and strengthened cause of Pakistan. He played major role in uniting the Sardars and Chiefs of Baluchistan for the cause of Pakistan and made Baluchistan join Pakistan according to the electoral principle set by 3 June 1947 Plan. Though, certain Sardars were against him because of his anti-Sardari system in Baluchistan, yet he successfully carried forward his stance. His services and contribution are addressed and discussed in detail in this paper.